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Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology by Adam Martersteck; Ivan Ayala; Daniel T. Ohm; Callen Spencer; Christina Coventry; Sandra Weintraub; Eileen H. Bigio; M. -Marsel Mesulam; Changiz Geula; Emily Rogalski is a Medicine article available to read on EtoBox.
What is Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology about?
Quantification of in vivo amyloid and tau PET imaging relationships with postmortem measurements are critical for validating the sensitivity and specificity imaging biomarkers across clinical phenotypes with Alzheimer disease neuropathologic change (ADNC). This study examined the quantitative relationship between regional binding of in vivo F-florbetapir amyloid PET and F-flortaucipir tau PET with postmortem stereological counts of amyloid plaques and neurofibrillary tangles (NFT) in a case of primary progressive aphasia (PPA) with ADNC, where neurodegeneration asymmetrically targets the left hemisphere. Beginning 2 years prior to death, a 63-year-old right-handed man presenting with agrammatic variant PPA underwent a florbetapir and flortaucpir PET scan, and neuropsychological assessments and magnetic resonance imaging sessions every 6 months. Florbetapir and flortaucpir PET standard uptake value ratios (SUVRs) were quantified from 8 left and right hemisphere brain regions with stereological quantification of amyloid plaques and NFTs from corresponding postmortem sections. Pearson's correlations and measures of asymmetry were used to examine relationships between imaging and autop
Who reads Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Adam Martersteck; Ivan Ayala; Daniel T. Ohm; Callen Spencer; Christina Coventry; Sandra Weintraub; Eileen H. Bigio; M. -Marsel Mesulam; Changiz Geula; Emily Rogalski
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)