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Can I read Heparinase Selectively Sheds Heparan Sulphate from the Endothelial Glycocalyx on EtoBox?
Heparinase Selectively Sheds Heparan Sulphate from the Endothelial Glycocalyx by Daniel Chappell; Matthias Jacob; Markus Rehm; Mechthild Stoeckelhuber; Ulrich Welsch; Peter Conzen; Bernhard F. Becker is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Heparinase Selectively Sheds Heparan Sulphate from the Endothelial Glycocalyx about?
## Abstract A healthy vascular endothelium is coated by the endothelial glycocalyx. Its main constituents are transmembrane syndecans and bound heparan sulphates. This structure maintains the physiological endothelial permeability barrier and prevents leukocyte and platelet adhesion, thereby mitigating inflammation and tissue oedema. Heparinase, a bacterial analogue to heparanase, is known to attack the glycocalyx. However, the exact extent and specificity of degradation is unresolved. We show by electron microscopy, immunohistological staining and quantitative measurements of the constituent parts, that heparinase selectively sheds heparan sulphate from the glycocalyx, but not the syndecans.
Who reads Heparinase Selectively Sheds Heparan Sulphate from the Endothelial Glycocalyx?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Daniel Chappell; Matthias Jacob; Markus Rehm; Mechthild Stoeckelhuber; Ulrich Welsch; Peter Conzen; Bernhard F. Becker
- Publisher
- Walter de Gruyter GmbH
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)