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Targeting Integrin V 3 With Indomethacin Inhibits Patient-Derived Xenograft Tumour Growth and Recurrence in Oesophageal Squamous Cell Carcinoma by fadimeelmast is a document available to read on EtoBox.
What is Targeting Integrin V 3 With Indomethacin Inhibits Patient-Derived Xenograft Tumour Growth and Recurrence in Oesophageal Squamous Cell Carcinoma about?
The study investigates the role of integrin αvβ3 in oesophageal squamous cell carcinoma (ESCC) and demonstrates that indomethacin can inhibit tumor growth and recurrence by targeting this integrin. Indomethacin promotes the degradation of integrin αvβ3 through SYVN1-mediated ubiquitination, leading to reduced tumor growth and enhanced anti-tumor immune responses in mouse models. These findings suggest that integrin αvβ3 is a promising therapeutic target for preventing ESCC recurrence.
- Author
- fadimeelmast
- Language
- EN