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Inflammatory and cytotoxic mediators in COVID-19 patients and in ChAdOx1 nCoV-19 (AZD1222) vaccine recipients 1 1 Introduction 1 2 Materials and methods 2 2.1 Study design and volunteers 2 2.2 Ethics Statement 2 2.3 Blood sample collection 2 2.4 SARS-CoV-2 serology 2 2.5 Inflammatory and cytotoxic mediators’ quantification 2 2.6 Statistical analysis 2 3 Results 3 3.1 Characteristics of SARS-CoV-2 patients and recipient vaccine individuals 3 3.2 Anti-S1 SARS-CoV-2 IgG detection in ChAdOx1 nCoV-19 (AZD1222) vaccine recipients compared to patients who infected SARS ... 3 3.3 Plasma inflammatory and cytotoxic profile induced by the ChAdOx1nCoV-19 (AZD1222) vaccine 4 3.4 Plasma inflammatory and cytotoxic profile induced by the SARS-CoV-2 infection 4 3.5 Comparison between cytokines and cytotoxic granules induced by the ChAdOx1nCoV-19 (AZD1222) vaccine and in natural infe ... 5 4 Discussion 5 CRediT authorship contribution statement 8 Declaration of Competing Interest 8 Data availability 8 Acknowledgement 8 References 8

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EN

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nonfiction