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Can I read Structural modifications of quinolone-3-carboxylic acids with anti-HIV activity on EtoBox?
Structural modifications of quinolone-3-carboxylic acids with anti-HIV activity by Qiu-Qin He; Shuang-Xi Gu; Jia Liu; Hai-Qiu Wu; Xuan Zhang; Liu-Meng Yang; Yong-Tang Zheng; Fen-Er Chen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Structural modifications of quinolone-3-carboxylic acids with anti-HIV activity about?
A series of new quinolone-3-carboxylic acids featuring a hydroxyl group at C-5 position were synthesized and evaluated for their in vitro activity against HIV in C8166 cell culture. All the compounds showed anti-HIV-1 activity with low micromolar to submicromolar EC 50 values. The most active compound 2k exhibited activity against wild-type HIV-1 with an EC 50 value of 0.13 lV. Preliminary structure-activity relationship of the newly synthesized quinolone analogues was also investigated. Further docking study revealed that the anti-HIV activity of these compounds might involve a two-metal chelating mechanism.
Who reads Structural modifications of quinolone-3-carboxylic acids with anti-HIV activity?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Qiu-Qin He; Shuang-Xi Gu; Jia Liu; Hai-Qiu Wu; Xuan Zhang; Liu-Meng Yang; Yong-Tang Zheng; Fen-Er Chen
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)