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Effects of pre- and postnatal corticosterone exposure on the rat hippocampal GABA system by David J. Stone; John P. Walsh; Ronnie Sebro; Renna Stevens; Harry Pantazopolous; Francine M. Benes is a Neuroscience article available to read on EtoBox.

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## Abstract Several lines of evidence have implicated prenatal stress and the hippocampal GABA system in the pathophysiology of schizophrenia, and prenatal stress is believed to increase the risk for schizophrenia through alterations of this neurotransmitter. To explore this hypothesis, we treated male rats pre‐ and/or postnatally (P48 and P60) with either corticosterone (CORT) or vehicle to establish three study groups: VVV, receiving vehicle at all three time points; VCC, receiving vehicle prenatally and CORT at both postnatal timepoints; and CCC, receiving CORT at all three timepoints. Animals were sacrificed at either 24 h or 5 days after final injection and examined for mRNA levels of GAD~65~, GAD~67~, and the GABA~A~ receptor subunits α~2~ and γ~2~. At 24 h, GAD~65~ mRNA was decreased in CA1, CA2, CA4, and dentate gyrus (DG) of VCC rats; this effect was either decreased or reversed in CCC‐treated animals. No effect was detected in GAD~67~ mRNA at 24 h. At 5 days, CORT treatment increased GAD~67~ mRNA levels in CA1, CA3, and DG. Prenatal treatment with CORT was associated with increased responsiveness only in CA3 and DG. For the GABA~A~ receptor, α~2~ subunit mRNA did not show

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Author

David J. Stone; John P. Walsh; Ronnie Sebro; Renna Stevens; Harry Pantazopolous; Francine M. Benes

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1050-9631)

Published

2001

Language

EN

Field

Neuroscience (Life Sciences)