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Perinatal Opiate Exposure - Effects on Metabolism of Xenobiotics and Steroids in Adult Rat Liver by Hansson, Tiiu; Näslund, Birgitta; Blanck, Agneta; Rane, Anders is a Medicine article available to read on EtoBox.

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The effects of perinatal or neonatal morphine exposure on the hepatic steroid and xenobiotic metabolism in adult rats were studied. Early morphine exposure did not affect the 16a-hydroxylation or 5a-reduction of androstenedione in either sex, but decreased the 7a-and 6ß-hydroxylations in both sexes. Morphine exerted a suppressive effect on the ethoxyresorufin-O-deethylase activity and increased the ethoxycoumarin-O-deethylase ac tivity in both sexes. Morphine exposure did not significantly affect its own N-demethylation or the total cytochrome P-450 content in the liver. Neonatal morphine exposure caused a significant decrease in body and testes weight in the adult male rat. We conclude that the effects of morphine are not confined to sex-differentiated pathways and are similar in both sexes. thalamic level [Gustafsson and Stenberg, 1974], The sexual dimorphism in liver me tabolism becomes manifest at the time of puberty. Other sex-differentiated functions that are imprinted neonatally include the gonadotropin secretion pattern and the sex ual behaviour [for review see Harlan et al., 1979]. The administration of opiates to adult rats has been shown to perturb the sex-differnetiated

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Author

Hansson, Tiiu; Näslund, Birgitta; Blanck, Agneta; Rane, Anders

Publisher

S. Karger AG (ISSN 0379-8305)

Published

1989

Language

EN

Field

Medicine (Health Sciences)