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Long-term Effects of Prenatal Alcohol Exposure on the Size of the Whisker Representation in Juvenile and Adult Rat Barrel Cortex by Tyson D. Chappell; Cecilia P. Margret; Cheng X. Li; Robert S. Waters is a Medicine article available to read on EtoBox.

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Children of mothers who abused alcohol during pregnancy are often reported to suffer from growth retardation and central nervous system (CNS) abnormalities. The use of prenatal alcohol exposed (PAE) animal models has revealed reductions in body and brain weights as well as regional specific brain deficits in neonatal pups. Recently, we and others reported reductions in the size of the posteromedial barrel subfield (PMBSF) in first somatosensory cortex (SI) associated with the representation of the large mystacial vibrissae in neonatal rats and mice that were exposed to alcohol at various times during gestation. While these reductions in barrel field size were reported in neonates, it was unclear whether similar reductions persisted later in life or whether some catch-up might take place in older animals. In the present study, we examined the effect of PAE on measures of barrel field size in juvenile (6 weeks of age) and adult (7 months of age) rats; body and brain weights were also measured. Pregnant rats (Sprague-Dawley) were intragastrically gavaged during gestational days 1-20 with alcohol (6 g/kg) to simulate a binge-like pattern of alcohol consumption (Alc); 6 g/kg alcohol pro

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Author

Tyson D. Chappell; Cecilia P. Margret; Cheng X. Li; Robert S. Waters

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0741-8329)

Published

2007

Language

EN

Field

Medicine (Health Sciences)