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Acceptance letter by L. Kaps; C. J. Ahlbrand; R. Gadban; M. Nagel; C. Labenz; P. Klimpke; S. Holtz; S. Boedecker; M. Michel; W. M. Kremer; M. Hilscher; P. R. Galle; D. Kraus; J. M. Schattenberg; J. Weinmann-Menke is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background ADVanced Organ Support (ADVOS) is a novel type of extracorporeal albumin dialysis and holds promise to sustain liver function and recovery of patients with acute-on-chronic liver failure (ACLF). Previously, ADVOS was tested as continuous treatment for intensive care patients with liver failure. Data related to the applicability and safety as discontinuous treatment outside of ICU is not available. ## Aim Evaluation of ADVOS as discontinuous treatment for patients with ACLF outside intensive care unit and comparison with a matched historic cohort. ## Methods and results In this retrospective study, 26 patients with ACLF and the indication for renal replacement therapy related to HRS-AKI were included. Majority of patients were male (65%) with alcoholic cirrhosis in 88% and infections as a trigger of ACLF in 96%. Liver function was severely compromised reflected by high median MELD and CLIF-C ACLF scores of 37 (IQR 32;40) and 56.5 (IQR 51;60), respectively. Patients were treated discontinuously with ADVOS over a median time of 12 days (IQR 8.25;17) and received 8 (IQR 4.25;9.75) treatment cycles on average. No treatment related adverse events were recorded, and safety l

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Author

L. Kaps; C. J. Ahlbrand; R. Gadban; M. Nagel; C. Labenz; P. Klimpke; S. Holtz; S. Boedecker; M. Michel; W. M. Kremer; M. Hilscher; P. R. Galle; D. Kraus; J. M. Schattenberg; J. Weinmann-Menke

Publisher

Public Library of Science (PLoS)

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)