Can I read Chloroquine–astemizole Hybrids with Potent in Vitro and in Vivo Antiplasmodial Activity on EtoBox?
Chloroquine–astemizole Hybrids with Potent in Vitro and in Vivo Antiplasmodial Activity by Chitalu C. Musonda; Gavin A. Whitlock; Michael J. Witty; Reto Brun; Marcel Kaiser is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Chloroquine–astemizole Hybrids with Potent in Vitro and in Vivo Antiplasmodial Activity about?
A dual activity, conjugated approach has been taken to form hybrid molecules of two known antimalarial drugs, chloroquine (CQ) and the non-sedating H1 antagonist astemizole. A variety of linkers were investigated to conjugate the two agents into one molecule. Compounds 5-8 possessed improved in vitro activity against a CQ-resistant strain of Plasmodium falciparum, and examples 7 and 8 were active in vivo in mouse models of malaria.
Who reads Chloroquine–astemizole Hybrids with Potent in Vitro and in Vivo Antiplasmodial Activity?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Chitalu C. Musonda; Gavin A. Whitlock; Michael J. Witty; Reto Brun; Marcel Kaiser
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)