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Can I read Comparison of Inhibitory Effects of Local Anesthetics on Immune Functions of Neutrophils on EtoBox?
Comparison of Inhibitory Effects of Local Anesthetics on Immune Functions of Neutrophils by Yasutaka Azuma; Mitsuko Shinohara; Pao-Li Wang; Yuichi Suese; Hideki Yasuda; Kiyoshi Ohura is a Immunology and Microbiology article available to read on EtoBox.
What is Comparison of Inhibitory Effects of Local Anesthetics on Immune Functions of Neutrophils about?
Immunological eects of a variety of local anesthetics on adhesion, phagocytosis, and the production of superoxide anion and hydrogen peroxide by neutrophils were compared. Neutrophils were isolated by peritoneal lavage from rats, 4 h after injection of 1% glycogen. Lidocaine, mepivacaine, procaine, prilocaine and tetracaine at 1 mg/ml inhibited adhesion, phagocytosis, and the production of superoxide anion and hydrogen peroxide in neutrophils. Moreover, lidocaine, mepivacaine, procaine and prilocaine at 0.1 mg/ml inhibited the production of superoxide anion and hydrogen peroxide but not adhesion or phagocytosis. In contrast, tetracaine at 0.1 mg/ml inhibited phagocytosis, and the production of superoxide anion and hydrogen peroxide but not adhesion. At 0.01 mg/ml, however, tetracaine inhibited the production of superoxide anion and hydrogen peroxide; in contrast, other drugs failed to aect neutrophil function. These results suggest that the local anesthetics may aect adhesion, phagocytosis, and the production of superoxide anion and hydrogen peroxide by neutrophils.
Who reads Comparison of Inhibitory Effects of Local Anesthetics on Immune Functions of Neutrophils?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Yasutaka Azuma; Mitsuko Shinohara; Pao-Li Wang; Yuichi Suese; Hideki Yasuda; Kiyoshi Ohura
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0192-0561)
- Published
- 2000
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)