Can I read Prolactinomas Express Human Heparin-binding Secretory Transforming Gene (Hst) Protein Product: Marker of Tumour Invasiveness: Hst Protein in Prolactinomas on EtoBox?

Prolactinomas Express Human Heparin-binding Secretory Transforming Gene (Hst) Protein Product: Marker of Tumour Invasiveness: Hst Protein in Prolactinomas by Ilan Shimon; David R. Hinton; Martin H. Weiss; Shlomo Melmed is a Medicine article available to read on EtoBox.

What is Prolactinomas Express Human Heparin-binding Secretory Transforming Gene (Hst) Protein Product: Marker of Tumour Invasiveness: Hst Protein in Prolactinomas about?

## Background and objective: We have shown previously that heparin-binding secretory transforming gene (hst) overexpression in rat pituitary cells mediates lactotroph tumour growth and stimulates prl transcription, and that transforming sequences of the gene, which encode fibroblast growth factor-4 (fgf-4), are expressed in human prolactinomas. to further determine the role of hst in human prl-secreting adenoma pathogenesis we studied the presence of hst protein in these tumours and other types of human pituitary adenoma. ## Patients and design: Pituitary adenoma tissue samples were obtained at surgery from 14 patients with prl-secreting adenomas, 5 patients with gh-secreting tumours, 3 with acth-secreting, and 13 patients with nonfunctioning tumours. two normal pituitary tissue specimens were also studied. clinical data, including tumour invasiveness assessed by preoperative mri studies, were available. for hst protein immunolocalization, tumour frozen sections were immunostained with antihuman fgf-4 antibody. immunoperoxidase staining for the proliferation-related nuclear antigen ki-67 was performed using mib-1 monoclonal antibody. ## Results: Normal anterior pituitary cells did

Who reads Prolactinomas Express Human Heparin-binding Secretory Transforming Gene (Hst) Protein Product: Marker of Tumour Invasiveness: Hst Protein in Prolactinomas?

Author

Ilan Shimon; David R. Hinton; Martin H. Weiss; Shlomo Melmed

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)

Published

1998

Language

EN

Field

Medicine (Health Sciences)