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Active Behavior of Triple-Negative Breast Cancer With Adipose Tissue Invasion: A Single Center and Retrospective Review by junzo yamaguchi; Hiroki Moriuchi; Takashi Ueda; Yujo Kawashita; Takanori Hazeyama; Masaki Tateishi; Shigehisa Aoki; Kazuyoshi Uchihashi; Mikio Nakamura is a scholarly article available to read on EtoBox.

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## Abstract BackgroundInteractions between adipocyte and breast cancer (BC) cells have yet to be fully elucidated. Here we investigated the prognostic impact of marginal adipose tissue invasion in both luminal breast cancer (HR+/HER2-) and triple-negative breast cancer (TNBC) (HR-/HER2-). MethodsA total of 735 patients with early-stage invasive BC (1999-2014) were retrospectively registered. Median length of patient follow-up was 8.9 years. Survival curves were calculated using a Kaplan-Meier cumulative survival plot. The prognostic difference between two groups were assessed by the univariate Cox-proportional hazard regression model.ResultsPatients with adipose tissue invasion (n = 614) had a significantly poorer prognosis than those without adipose tissue invasion (n = 121) in overall survival (OS) (hazard ratio, 2.1; 95% Confidence interval [CI], 1.1 to 4.0; P = 0.025). While a poorer prognosis was observed in TNBC (n = 137) than in luminal BC patients (n = 496) (hazard ratio, 0.45; 95% CI, 0.30 to 0.68, P < 0.001), this aggressive nature of TNBC was noted in node-positive disease (hazard ratio, 0.3; 95% CI, 0.18 to 0.5, P < 0.001) but not in node-negative disease (hazard ratio,

Author

junzo yamaguchi; Hiroki Moriuchi; Takashi Ueda; Yujo Kawashita; Takanori Hazeyama; Masaki Tateishi; Shigehisa Aoki; Kazuyoshi Uchihashi; Mikio Nakamura

Publisher

Research Square Platform LLC

Published

2021

Language

EN