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Can I read Characterization of the serotoninergic system in the C57BL/6 mouse skin on EtoBox?
Characterization of the serotoninergic system in the C57BL/6 mouse skin by Andrzej Slominski; Alexander Pisarchik; Igor Semak; Trevor Sweatman; Jacobo Wortsman is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Characterization of the serotoninergic system in the C57BL/6 mouse skin about?
We showed expression of the tryptophan hydroxylase gene and of tryptophan hydroxylase protein immunoreactivity in mouse skin and skin cells. Extracts from skin and melanocyte samples acetylated serotonin to __N__‐acetylserotonin and tryptamine to __N__‐acetyltryptamine. A different enzyme from arylalkylamine __N__‐acetyltransferase mediated this reaction, as this gene was defective in the C57BL6 mouse, coding predominantly for a protein without enzymatic activity. Serotonin (but not tryptamine) acetylation varied according to hair cycle phase and anatomic location. Serotonin was also metabolized to 5‐hydroxytryptophol and 5‐hydroxyindole acetic acid, probably through stepwise transformation catalyzed by monoamine oxidase, aldehyde dehydrogenase and aldehyde reductase. Activity of the melatonin‐forming enzyme hydroxyindole‐__O__‐methyltransferase was notably below detectable levels in all samples of mouse corporal skin, although it was detectable at low levels in the ears and in Cloudman melanoma (derived from the DBA/2 J mouse strain). In conclusion, mouse skin has the molecular and biochemical apparatus necessary to produce and metabolize serotonin and __N__‐acetylserotonin, and i
Who reads Characterization of the serotoninergic system in the C57BL/6 mouse skin?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Andrzej Slominski; Alexander Pisarchik; Igor Semak; Trevor Sweatman; Jacobo Wortsman
- Publisher
- John Wiley and Sons; Springer; Wiley (Blackwell Publishing); Springer-Verlag; Blackwell Publishing Inc.; Springer Verlag; Wiley; Springer Science and Business Media LLC (ISSN 1432-1327)
- Published
- 2003
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)