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Posttranslational Modification and Processing of Membrane Lipoproteins in Bacteria by Henry C. Wu; Masao Tokunaga; Hiroko Tokunaga; Shigeru Hayashi; Chou-Zen Giam is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Posttranslational Modification and Processing of Membrane Lipoproteins in Bacteria about?

Braun's lipoprotein is a major outer membrane protein in Escherichia coli and other gram-negative bacteria [I]. The biosynthesis of this protein has many unique features which have been extensively investigated [ 2 4 ] . The pathway for the biosynthesis of Braun's lipoprotein as it is currently understood is summarized in Figure 1 [5,6]. Biosynthesis of lipoprotein, as envisaged in this scheme, would require the specific products of seven genes. However, only one of these genes (the structural gene for the lipoprotein, Zpp) has thus far been identified and characterized [7-91. The genes encoding the modification and processing enzymes remain to be identified. Braun's lipoprotein is one of many outer membrane proteins which are synthesized first as precursor proteins and subsequently processed to their mature forms. The processing of prolipoprotein, however, appears to follow a pathway distinct from those shared by many other outer membrane and periplasmic proteins. The first clue as to the unique mechanism of processing of prolipoprotein derived from the discovery of a novel cyclic peptide antibiotic, globomycin (Fig. 2) [lo]. The work of Arai and his co-workers on the mode of acti

Who reads Posttranslational Modification and Processing of Membrane Lipoproteins in Bacteria?

Author

Henry C. Wu; Masao Tokunaga; Hiroko Tokunaga; Shigeru Hayashi; Chou-Zen Giam

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

1982

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)