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Salivary and serum IgA antibodies to the epstein—barr virus glycoprotein gp340: incidence and potential for virus neutralization by Q. Y. Yao; M. Rowe; A. J. Morgan; C. K. Sam; U. Prasad; H. Dang; Y. Zeng; A. B. Rickinson is a Medicine article available to read on EtoBox.

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## Abstract Human antibody responses to the Epstein—Barr virus (EBV) glycoprotein gp340 have been measured using purified preparations of the native molecule as the substrate in ELISAs. This glycoprotein is the dominant component of the EBV envelope and a major target for the virus—neutralizing antibody response. Healthy virus carriers (both Caucasian and Chinese) regularly show detectable anti—gp340 IgG in serum and, unexpectedly, 21–30% of these individuals are also serum anti—gp340 IgA positive. Chinese patients with the EBV—genome—positive malignancy nasopharyngeal carcinoma (NPC) show elevated serum IgA antibodies to gp340 but, given the background of responses amongst healthy virus carriers, anti—gp340 IgA titres are a __poorer__ diagnostic indicator of NPC than serum IgA antibodies detectable by immunofluorescence against the multicomponent EBV early antigen (EA). Salivary IgA antibody responses to gp340 are potentially important as a means of neutralizing orally—transmitted virus. We detected salivary IgA (but not IgG) to gp340 in a minority (12–19%) of healthy virus carriers and in a higher proportion (49%) of NPC patients. Even saliva samples chosen for their relatively h

Who reads Salivary and serum IgA antibodies to the epstein—barr virus glycoprotein gp340: incidence and potential for virus neutralization?

Author

Q. Y. Yao; M. Rowe; A. J. Morgan; C. K. Sam; U. Prasad; H. Dang; Y. Zeng; A. B. Rickinson

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1991

Language

EN

Field

Medicine (Health Sciences)