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Contrast agent stability: a continuous B-mode imaging approach by V Sboros; C.M Moran; S.D Pye; W.N McDicken is a Medicine article available to read on EtoBox.

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The stability of contrast agents in suspensions with various dissolved gas levels has not been reported in the literature. An in vitro investigation has been carried out that studied the combined effect of varying the acoustic pressure along with degassing the suspension environment. In this study, the contrast agents were introduced into suspensions with different oxygen concentration levels, and their relative performance was assessed in terms of decay rate of their backscatter echoes. The partial pressures of oxygen in those solutions ranged between 1.5 and 26 kPa. Two IV and one arterial contrast agents were used: Definity, QuantisonTM, and MyomapTM. It was found that QuantisonTM and MyomapTM released free bubbles at high acoustic pressure that also dissolved faster in degassed suspensions. The backscatter decay for Definity did not depend on the air content of the suspensions. The destruction of bubbles was dependent on acoustic pressure. Different backscatter performance was observed by different populations of bubbles of the last two agents. The physical quantity of "overall backscatter" (OB) was defined as the integral of the decay rate over time of the backscatter of the c

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Author

V Sboros; C.M Moran; S.D Pye; W.N McDicken

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0301-5629)

Published

2001

Language

EN

Field

Medicine (Health Sciences)