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The Developmental Sequence of Gene Expression Within the Rod Photoreceptor Lineage in Embryonic Zebrafish by Steve M. Nelson; Ruth A. Frey; Sheri L. Wardwell; Deborah L. Stenkamp is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract In postembryonic zebrafish, rod photoreceptors are continuously generated from progenitors in the inner nuclear layer, which are derived from radial Müller glia that express the transcription factor __pax6__. We used BrdU incorporation, in combination with in situ hybridization for cell‐specific transcription factors, to establish the patterns of gene expression during rod lineage maturation in the embryonic zebrafish. Downregulation of __pax6__ expression was accompanied by sporadic upregulation of expression of the transcription factors __NeuroD/nrd, rx1, crx__, and __Nr2e3/pnr__. As cells of the rod lineage entered the outer nuclear layer, they became homogeneous, coordinately expressing __NeuroD, rx1, crx__, and __Nr2e3__. Postmitotic, maturing rods also expressed __nrl, rod opsin__, and __rod transducin/gnat1__. The presence of __rx1__ within the rod lineage and in maturing rods indicates that __rx1__ is not cone‐specific, as previously reported, and suggests a high degree of molecular similarity between rod and cone progenitor populations in the zebrafish. Developmental Dynamics 237:2903–1917, 2008. © 2008 Wiley‐Liss, Inc.

Who reads The Developmental Sequence of Gene Expression Within the Rod Photoreceptor Lineage in Embryonic Zebrafish?

Author

Steve M. Nelson; Ruth A. Frey; Sheri L. Wardwell; Deborah L. Stenkamp

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1058-8388)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)