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Low serum vitamin B12 is associated with recurrent pregnancy loss in Syrian women by Ulrich Hübner; Ahmad Alwan; Muhidin Jouma; Mohammad Tabbaa; Heike Schorr; Wolfgang Herrmann is a Medicine article available to read on EtoBox.
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## Abstract : Hyperhomocysteinemia and B-vitamin deficiency are associated with recurrent abortion. Recent studies have not investigated functional markers of vitamin B12 deficiency, such as methylmalonic acid. : A total of 43 consecutive Syrian women with unexplained recurrent abortion and 32 pregnant controls were enrolled in the study. Serum folate, vitamin B12, methylmalonic acid and plasma homocysteine were determined. : Vitamin B12 was significantly decreased in patients with recurrent abortion compared to controls (mean concentrations 197 vs. 300 pg/mL, p=0.004). The lowest mean serum vitamin B12 (172 pg/mL) was observed in primary aborters. Homocysteine was elevated in aborters in comparison to controls (8.3 vs. 7.1 μmol/L, p=0.093). Folate and methylmalonic acid did not differ significantly between the study groups. A highly significant correlation between homocysteine and methylmalonic acid and vitamin B12 was observed only in patients but not in controls (p<0.001 and p=0.002, respectively). In the logistic regression model, only serum vitamin B12 emerged with a significant odds ratio. : The results confirm low serum vitamin B12 in recurrent abortion patients. However, me
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- Author
- Ulrich Hübner; Ahmad Alwan; Muhidin Jouma; Mohammad Tabbaa; Heike Schorr; Wolfgang Herrmann
- Publisher
- Walter de Gruyter GmbH
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)