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Can I read Role of protein kinase C in glial cell proliferation on EtoBox?
Role of protein kinase C in glial cell proliferation by N. R. Bhat is a Neuroscience article available to read on EtoBox.
What is Role of protein kinase C in glial cell proliferation about?
Phorbol 12-myristate 13-acetate (PMA) has been shown to stimulate DNA synthesis and cell proliferation in a population of glial cells isolated from newborn rat brain. The non-tumor promoter 4a-phorbol l2,13-didecanoate (4a-PDD), on the other hand, was without an effect. The cultures treated with PMA displayed an extensive process formation and an increase in cell content. The tumor promoter-induced [3H]thymidine incorporation into acid-precipitable material was completely blocked by 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine @I->, a potent inhibitor of protein kinase C (PKC), thereby suggesting a role for PKC in the control of DNA synthesis in glial cells. Subcellular fractionation and in vitro assay of PKC activity revealed a translocation of the enzyme from cytosol to particulate fraction in PMA-treated cultures.
Who reads Role of protein kinase C in glial cell proliferation?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- N. R. Bhat
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 1989
- Language
- EN
- Field
- Neuroscience (Life Sciences)