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Accelerated Growth of Preosteoblastic Cells on Ultrafine Grained Titanium by Y. Estrin; C. Kasper; S. Diederichs; R. Lapovok is a Engineering article available to read on EtoBox.

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## Abstract This work is part of a general effort to demonstrate the effect of the bulk microstructure of titanium as a model bone implant material on viability of osteoblasts (bone‐forming cells). The objective of this work was to study the proliferation of preosteoblastic MC3T3‐E1 cells extracted from mice embryos on commercial purity titanium substrates. Two distinct states of titanium were considered: as‐received material with an average grain size of 4.5 μm and that processed by equal channel angular pressing (ECAP), with an average grain size of 200 nm. We report the first results of an __in vitro__ study into the effect of this extreme grain refinement on viability and proliferation of MC3T3‐E1 cells. By means of MTT assays it was demonstrated that ECAP processing of titanium enhances MC3T3‐E1 culture proliferation in a spectacular way. This finding suggests that bone implants made from ECAP processed titanium may promote bone tissue growth. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009

Who reads Accelerated Growth of Preosteoblastic Cells on Ultrafine Grained Titanium?

Author

Y. Estrin; C. Kasper; S. Diederichs; R. Lapovok

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2008

Language

EN

Field

Engineering (Physical Sciences)