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Relationship between asthma and gastro-oesophageal reflux: Significance of endoscopic grade of reflux oesophagitis in adult asthmatics by Hiroshi Nakase; Toshinao Itani; Jun Mimura; Toshihiko Kawasaki; Hideshi Komori; Hiromi Tomioka; Tsutomu Chiba is a Medicine article available to read on EtoBox.
What is Relationship between asthma and gastro-oesophageal reflux: Significance of endoscopic grade of reflux oesophagitis in adult asthmatics about?
__Background__: The association between asthma and gastro‐oesophageal reflux disease (GERD) is well known. The aim of this study was to elucidate the causal relationship between reflux oesophagitis (RE) and asthma. __Methods: Seventy‐two adult asthmatics were examined regarding their GERD symptoms, and each underwent an endoscopic examination. According to the Los Angeles classification, we divided the patients into three groups: group 1 (n = 52), no mucosal break; group 2 (n = 15), RE corresponding to grades A or B; group 3 (n__ = 5), RE corresponding to grades C or D. The asthmatics in groups 2 and 3 received anti‐reflux treatment for their GERD for 8 weeks. Their morning and evening peak expiratory flow rates (PEFR), daily variability of the PEFR and daily use of an inhalation bronchodilator were compared before and after this treatment. __Results__: The percentage of severe asthma and postprandial exacerbation of asthma in group 3 were significantly higher than those in the other two groups. In contrast, the number of eosinophiles and the serum level of immunoglobulin E in group 3 were significantly lower than those in the other two groups. After the antireflux treatment, signi
Who reads Relationship between asthma and gastro-oesophageal reflux: Significance of endoscopic grade of reflux oesophagitis in adult asthmatics?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hiroshi Nakase; Toshinao Itani; Jun Mimura; Toshihiko Kawasaki; Hideshi Komori; Hiromi Tomioka; Tsutomu Chiba
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0815-9319)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)