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The document introduces singIST, an R/Bioconductor package designed for automated single-cell comparative transcriptomics analysis, enabling the comparison of disease model scRNA-seq data against human references. It features an adaptive sparse multi-block PLS-DA model to compute recapitulation metrics at various biological levels and includes a companion dashboard for visualizing results. The package aims to enhance the translational value of preclinical disease models by providing insights into cell type

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prem.pics9

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EN