Can I read Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans on EtoBox?

Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans by Natalie J. Wallis†, Alyce McClellan†, Alexander Mörseburg, Katherine A. Kentistou, Aqfan Jamaluddin, is a book available to read on EtoBox.

What is Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans about?

INTRODUCTION: Obesity is a heritable disease,with canine adiposity highlight genes that areIn cell models, overexpression of DENND1B inbut its genetic basis is incompletely understood,also relevant to human obesity.creased MC4R internalization after ligandand moving from common genetic associationsactivation and reduced cyclic adenosine 3′,5′-to mechanistic insight has proven challenging.RESULTS:In 241 adult pet Labrador retrievers,monophosphate (cAMP) signaling, with the conHypothalamic leptin-melanocortin signaling iswe performed a genome-wide association studyverse effect on DENND1B knockdown. By cona critical nexus of the central control of energy(GWAS) for body condition score (BCS), a meatrast, there was no such effect on the orexigenicbalance that integrates peripheral signals ofsure of canine adiposity. The top associationreceptor, growth hormone secretagogue recepenergy status, translating them into alterawas intronic within the gene DENN domaintor (GHSR).tions in energy expenditure and eating behavcontaining 1B (DENND1B). Each allele of theA canine polygenic risk score (PRS) improvedior to maintain energy homeostasis.lead variant in dogs conferred ~7.5% higher body

Author

Natalie J. Wallis†, Alyce McClellan†, Alexander Mörseburg, Katherine A. Kentistou, Aqfan Jamaluddin,

Published

2025

Language

EN