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Integrated analysis of miRNA and mRNA expression profiles in response to gut microbiota depletion in the abdomens of female Bactrocera dorsalis by Junfei Xie; Zhaohui Cai; Wenping Zheng; Hongyu Zhang is a Agricultural and Biological Sciences article available to read on EtoBox.

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## Abstract Insect gut microbiota has been reported to participate in regulating host multiple biological processes including metabolism and reproduction. However, the corresponding molecular mechanisms remain largely unknown. Recent studies suggest that microRNAs (miRNAs) are involved in complex interactions between the gut microbiota and the host. Here, we used next‐generation sequencing technology to characterize miRNA and mRNA expression profiles and construct the miRNA–gene regulatory network in response to gut microbiota depletion in the abdomens of female Bactrocera dorsalis. A total of 3016 differentially expressed genes (DEGs) and 18 differentially expressed miRNAs (DEMs) were identified. Based on the integrated analysis of miRNA and mRNA sequencing data, 229 negatively correlated miRNA–gene pairs were identified from the miRNA–mRNA network. Gene ontology enrichment analysis indicated that DEMs could target several genes involved in the metabolic process, oxidation–reduction process, oogenesis, and insulin signaling pathway. Finally, real‐time quantitative polymerase chain reaction further verified the accuracy of RNA sequencing results. In conclusion, our study provides t

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Author

Junfei Xie; Zhaohui Cai; Wenping Zheng; Hongyu Zhang

Publisher

Wiley

Published

2022

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)