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Effects of Low Electrolyte Media on Salt Loss and Hemolysis of Mammalian Red Blood Cells by R. B. Zeidler; H. D. Kim is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Cation loss and hemolysis of various mammalian red cells suspended in isotonic non‐electrolyte media were investigated. Sucrose buffered with 10 mM Tris‐Hepes, pH 7.4 was used as the non‐permeable non‐electrolyte. Mammals from which the red cells were derived include the human, guinea pig, rat, rabbit, newborn calf, newborn piglet and pig, all of which contain K as the predominant cation species (HK type) and the dog, cat, sheep and cow, all of which possess Na as the predominant cation species (LK type). Of HK cells, a rapid efflux of K takes place from humans, rats and guinea pigs. Of LK type cells, the dog and cat exhibit an augmented membrane permeability to Na. The governing factors which influence cation permeability are the change in pH, temperature, and ionic strength. In response to increase in pH, the red cells of humans, dogs and cats become more permeable to cations, whereas the red cells of rat and rabbit are unaffected. In response to increase in temperature, HK type cells exhibit augmented K efflux, while the Na loss from the dog and cat cells manifest a well‐defined maximum at near 37°C. In all cases, a small substitution of sucrose by an equal number of

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Author

R. B. Zeidler; H. D. Kim

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

1979

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)