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Involvement of Nitric Oxide in Pentylenetetrazole-Induced Kindling in Rats by Daiken Han; Kiyofumi Yamada; Kouji Senzaki; Huabao Xiong; Hiroyuki Nawa; Toshitaka Nabeshima is a Neuroscience article available to read on EtoBox.

What is Involvement of Nitric Oxide in Pentylenetetrazole-Induced Kindling in Rats about?

**Abstract:** We investigated the role of nitric oxide (NO) and brain‐derived neurotrophic factor (BDNF) in the pentylenetetrazole (PTZ)‐induced kindling in rats. Seizures were induced by single administration of PTZ, which was associated with an increase in levels of NO metabolites (NO~x~) in the hippocampus. Pretreatment with a neuronal NO synthase inhibitor, 7‐nitroindazole (7‐NI), diminished the PTZ‐induced increase in NO~x~ levels without affecting the seizure intensity. Repeated administration of PTZ produced a gradual increase in the seizure intensity, leading to the development of kindling. In the kindled rats, PTZ at a dose of 40 mg/kg increased NO~x~ levels in the hippocampus, whereas it had no effect in control animals. Cotreatment of 7‐NI with PTZ blocked the development of kindling and attenuated the PTZ‐induced increase in NO~x~ levels. A significant increase in BDNF levels was observed in the hippocampus of the kindled rats, which returned to the control levels following seizures induced by PTZ. 7‐NI reduced the hippocampal BDNF levels in control rats and suppressed the increase of BDNF levels in the kindled rats. Our findings suggest that NO plays a role in the deve

Who reads Involvement of Nitric Oxide in Pentylenetetrazole-Induced Kindling in Rats?

Author

Daiken Han; Kiyofumi Yamada; Kouji Senzaki; Huabao Xiong; Hiroyuki Nawa; Toshitaka Nabeshima

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)

Published

2000

Language

EN

Field

Neuroscience (Life Sciences)