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Feasibility and Efficacy of External Beam Radiotherapy after Hyperthermic Isolated Limb Perfusion with TNF-α and Melphalan for Limb-saving Treatment in Locally Advanced Extremity Soft-tissue Sarcoma by Annette F.T Olieman M.D.; Elisabeth Pras M.D.; Robert J van Ginkel M.D.; Willemina M Molenaar M.D., Ph.D.; Heimen Schraffordt Koops M.D., Ph.D.; Harald J Hoekstra M.D., Ph.D. is a Medicine article available to read on EtoBox.

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Purpose: Hyperthermic isolated limb perfusion (HILP) with tumor necrosis factor-␣ (TNF-␣), interferon-␥ (IFN-␥), and melphalan is associated with a dramatic antitumor effect in locally advanced extremity soft-tissue sarcomas (STS). The aim of this study was to demonstrate the feasibility and efficacy of adjuvant radiotherapy after HILP with TNF-␣, IFN-␥, and melphalan and delayed surgical resection. Methods and Materials: Between 1991 and 1995, 34 patients-16 males and 18 females, median age 50 (range 18 -80) years-underwent HILP for locally advanced extremity STS. Resection of the residual tumor mass was performed in most patients after 6 -8 weeks. Fifteen patients with histopathological viable tumor after resection received adjuvent 60 -70 Gy external beam radiotherapy (EBRT) (44%, HILP ؉ EBRT group). Nineteen patients received HILP without adjuvent EBRT (56%, HILP-only group). Five patients in the HILP-only group had also distant metastases (15%) and received HILP as a palliative treatment. Treatment morbidity, local recurrences, and regional and distant metastases were scored. Results: During a median follow-up of 34 months (range 8 -54), limb salvage was achieved in 29 patient

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Author

Annette F.T Olieman M.D.; Elisabeth Pras M.D.; Robert J van Ginkel M.D.; Willemina M Molenaar M.D., Ph.D.; Heimen Schraffordt Koops M.D., Ph.D.; Harald J Hoekstra M.D., Ph.D.

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

1998

Language

EN

Field

Medicine (Health Sciences)