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Can I read Real‐life experience with the combination of polatuzumab vedotin, rituximab, and bendamustine in aggressive B‐cell lymphomas on EtoBox?
Real‐life experience with the combination of polatuzumab vedotin, rituximab, and bendamustine in aggressive B‐cell lymphomas by Maria Dimou; Sotirios G. Papageorgiou; Niki Stavroyianni; Eirini Katodritou; Maria Tsirogianni; Christina Kalpadakis; Anastasia Banti; Maria Arapaki; Theodoros Iliakis; Maria Bouzani; Eugenia Verrou; Emmanouil Spanoudakis; Stavroula Giannouli; Theodoros Marinakis; Evdokia Mandala; Despoina Mparmparousi; Sotirios Sachanas; Maria Dalekou‐Tsolakou; Eleftheria Hatzimichael; Chryssa Vadikolia; Vasiliki Violaki; Christos Poziopoulos; Pantelis Tsirkinidis; Sofia Chatzileontiadou; Elissavet Vervessou; Maria Ximeri; Anastasia Sioni; Pavlina Konstantinidou; Marie‐Christine Kyrtsonis; Marina P. Siakantaris; Maria K. Angelopoulou; Vassiliki Pappa; Kostas Konstantopoulos; Panayiotis Panayiotidis; Theodoros P. Vassilakopoulos is a Medicine article available to read on EtoBox.
What is Real‐life experience with the combination of polatuzumab vedotin, rituximab, and bendamustine in aggressive B‐cell lymphomas about?
## Abstract Transplant‐ineligible relapsed/refractory (rr) diffuse large B‐cell lymphoma (DLBCL) patients represent an unmet medical need. Polatuzumab vedotin (Pola), an anti‐CD79b antibody‐drug‐conjugate (ADG), with bendamustine‐ rituximab(BR) has recently gained approval for these patients, both in the USA and Europe, based on the GO29365 phase IIb trial. Real‐life data with Pola are extremely limited. We report the outcomes of 61 Greek patients, who received Pola‐(B)R mainly within a compassionate use program. Treatment was given for up to six 21‐day cycles. Bendamustine was omitted in three cases due to previous short‐lived responses. Fourty‐nine rrDLBCL(efficacy cohort‐EC) and 58 rr aggressive B‐NHL (safety cohort‐SC) patients received at least 1 Pola‐BR cycle. Twenty‐one (43%) patients of the EC responded with 12/49 (25%) CR and 9/49 (18%) PR as best response. Median progression–free survival, overall survival and duration of response were 4.0, 8.5, and 8.5 months respectively, while 55% of patients experienced a grade ≥3 adverse event, mainly hematologic. Treatment discontinuations and death during treatment were mainly due to disease progression. Twenty‐two (41%) patients r
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- Author
- Maria Dimou; Sotirios G. Papageorgiou; Niki Stavroyianni; Eirini Katodritou; Maria Tsirogianni; Christina Kalpadakis; Anastasia Banti; Maria Arapaki; Theodoros Iliakis; Maria Bouzani; Eugenia Verrou; Emmanouil Spanoudakis; Stavroula Giannouli; Theodoros Marinakis; Evdokia Mandala; Despoina Mparmparousi; Sotirios Sachanas; Maria Dalekou‐Tsolakou; Eleftheria Hatzimichael; Chryssa Vadikolia; Vasiliki Violaki; Christos Poziopoulos; Pantelis Tsirkinidis; Sofia Chatzileontiadou; Elissavet Vervessou; Maria Ximeri; Anastasia Sioni; Pavlina Konstantinidou; Marie‐Christine Kyrtsonis; Marina P. Siakantaris; Maria K. Angelopoulou; Vassiliki Pappa; Kostas Konstantopoulos; Panayiotis Panayiotidis; Theodoros P. Vassilakopoulos
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)