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Can I read c‐Jun amplification and overexpression are oncogenic in liposarcoma but not always sufficient to inhibit the adipocytic differentiation programme on EtoBox?
c‐Jun amplification and overexpression are oncogenic in liposarcoma but not always sufficient to inhibit the adipocytic differentiation programme by Eric L Snyder; Deborah J Sandstrom; Kenneth Law; Christopher Fiore; Ewa Sicinska; Joseph Brito; Dyane Bailey; Jonathan A Fletcher; Massimo Loda; Scott J Rodig; Paola Dal Cin; Christopher DM Fletcher is a Medicine article available to read on EtoBox.
What is c‐Jun amplification and overexpression are oncogenic in liposarcoma but not always sufficient to inhibit the adipocytic differentiation programme about?
## Abstract Genomic amplification of __c‐Jun__ and its upstream kinases have been implicated as a mechanism of progression from well‐differentiated to dedifferentiated liposarcoma. To further define the role of c‐Jun in liposarcoma progression, we performed immunohistochemistry for c‐Jun and its activating kinase ASK1 on a series of liposarcomas (__n__ = 81). We correlated the results with fluorescence __in situ__ hybridization to detect __c‐Jun__ amplification. We also derived new cell lines from dedifferentiated liposarcomas with __c‐Jun__ amplification. c‐Jun protein is expressed in the majority of dedifferentiated liposarcomas (91%) and their well‐differentiated components (59%), but only in the minority of pure well‐differentiated liposarcomas (27%). When __c‐Jun__ is amplified in dedifferentiated liposarcoma, it is interspersed with amplified __MDM2__ on ring and giant marker chromosomes. __MDM2__ amplification is one of the earliest events in liposarcoma development, and these results suggest that __c‐Jun__ was amplified at a similar time in the evolution of the tumour. In addition, shRNA to c‐Jun in __c‐Jun__‐amplified liposarcoma cells reduces cell number __in vitro__ and
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- Author
- Eric L Snyder; Deborah J Sandstrom; Kenneth Law; Christopher Fiore; Ewa Sicinska; Joseph Brito; Dyane Bailey; Jonathan A Fletcher; Massimo Loda; Scott J Rodig; Paola Dal Cin; Christopher DM Fletcher
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)