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Agmatine Attenuates Rhabdomyolysis-induced Acute Kidney Injury in Rats in a Dose Dependent Manner by Maha H. Sharawy; Rehab S. Abdelrahman; Dalia H. El-Kashef is a Neuroscience article available to read on EtoBox.

What is Agmatine Attenuates Rhabdomyolysis-induced Acute Kidney Injury in Rats in a Dose Dependent Manner about?

Acute kidney injury (AKI) is a serious disorder that accompanies rhabdomyolysis (RM). The underlying mechanisms as well as protective approaches need to be investigated. This study was targeted to explore the prophylactic effect of agmatine (AGM), an endogenous metabolite of l-arginine against RM-induced AKI. A rat model was elucidated by 50% glycerol (10 ml/kg, im). Glycerol induced functional and structural alterations in the kidney. Pretreatment with AGM significantly ameliorated RM through decreasing total creatinine kinase (CK) and creatine kinase-MB (CK-MB) levels. AGM alleviated functional changes evidenced by decreased serum levels of creatinine (Cr), blood urea nitrogen (BUN) and decreased urinary levels of albumin and proteins. Moreover, AGM decreased renal levels of malondialdehyde (MDA), nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), interleukin 1-beta (IL-1β), neutrophil gelatinase-associated lipocalin (NGAL), inducible nitric oxide synthase (iNOS), nuclear factor kappa B (NF-κB) and myeloperoxidase (MPO). Furthermore, AGM significantly increased renal levels of reduced glutathione (GSH), superoxide dismutase (SOD), nuclear factor erythroid 2-related factor 2

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Author

Maha H. Sharawy; Rehab S. Abdelrahman; Dalia H. El-Kashef

Published

2018

Language

EN

Field

Neuroscience (Life Sciences)