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What is Centrosome Dynamics and Cancer Instability about?

This review discusses centrosome dynamics and how abnormalities can lead to chromosomal instability and cancer. It describes the normal structure and duplication of centrosomes. Centrosome duplication occurs in G1/S and consists of 4 stages: disengagement of centriole pairs, duplication of each centriole, elongation of new centrioles, and maturation of centrosome material. Centrosome dynamics in G2/M involves disjunction of centrosomes followed by motor protein-driven movement to opposite spindle poles. The

Author

Eugenia Alaniz Fierro

Language

EN