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Can I read Diurnal Rhythm in Serum Leptin on EtoBox?
Diurnal Rhythm in Serum Leptin by O.D. Wolthers; C. Heuck; C. Skjaerbask is a Medicine article available to read on EtoBox.
What is Diurnal Rhythm in Serum Leptin about?
Aim: To assess 24-hour serum leptin levels in children. Subjects and methods: Five girls and two boys aged 10.4-13.6 (mean 12.2) years with pubertal stages I to III were studied. All children were healthy. A fasting blood sample was drawn at 08.00 hours, and thereafter samples were obtained every 2 hours throughout 24 hours until 08.00 hours the next morning. Serum leptin was measured by a specific radioimmunoassay. Results: A statistically significant circadian variation was found in mean leptin profile expressed as a percentage of overall day mean (F-ratio =10.4; P<0.001) with trough and peak levels (± SEM) at 10.00 (6.55 ± 1.52 mg/1) and 24.00 hours (10.99 ± 2.34 mg/1), respectively. Conclusions: In normal children serum leptin levels exhibit a nocturnal increase and a decrease during the morning. The nocturnal rise may represent a time lagged stimulating effect of insulin. The diurnal rhythm needs to be considered when serum leptin is assessed in clinical studies.
Who reads Diurnal Rhythm in Serum Leptin?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- O.D. Wolthers; C. Heuck; C. Skjaerbask
- Published
- 1999
- Language
- CY
- Field
- Medicine (Health Sciences)