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Pharmaceutical Metabolic Down-regulation by Protein Synthesis Inhibition in a Conscious Rat Model by Penny S. Reynolds; R. Wayne Barbee; Kevin R. Ward is a Medicine article available to read on EtoBox.

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Pharmaceutically induced metabolic down-regulation may be a useful therapeutic adjunct when tissue oxygen supply is restricted. We hypothesized that protein synthesis inhibition in a non-hibernating species should lower oxygen demand, resulting in aerobic metabolic rate depression at the whole animal level. We compared metabolic responses and measures of systemic oxygenation of conscious catheterized rats given either protein synthesis inhibition (PSI) agents or carrier controls (normal saline and DMSO). Core temperature was measured by implanted transmitters, and VO 2 was determined in an open flow-through metabolic chamber at 25 • C. Mean arterial pressure MAP and heart rate HR were determined from arterial pressure transducer tracings; arterial blood gases and lactate were sampled every 15 min. PSI rats exhibited an immediate transient decline in VO 2 , followed by a secondary decline to new resting levels; VO 2 for the first hour was significantly lower than that for rats receiving DMSO vehicle. Unlike controls, PSI rats showed an overall 3.5 • C decline in core temperature, coupled with increased arterial lactate. There were no differences in MAP and HR of PSI rats compared to

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Author

Penny S. Reynolds; R. Wayne Barbee; Kevin R. Ward

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-9572)

Published

2007

Language

EN

Field

Medicine (Health Sciences)