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Click Postsynthesis of Microporous Organic Network@silica Composites for Reversed-phase/hydrophilic Interaction Mixed-mode Chromatography by Hao-Fei Sun; Yuan-Yuan Cui; Hong-Liang Li; Cheng-Xiong Yang is a Chemistry article available to read on EtoBox.

What is Click Postsynthesis of Microporous Organic Network@silica Composites for Reversed-phase/hydrophilic Interaction Mixed-mode Chromatography about?

Recently, the good physical and chemical properties, well-defined pore architectures, and designable topologies have made microporous organic networks (MONs) excellent potential candidates in high-performance liquid chromatography (HPLC). However, their superior hydrophobic structures restrict their application in the reversed-phase mode. To solve this obstacle and to expand the application of MONs in HPLC, we realized the thiol-yne "click" postsynthesis of a novel hydrophilic MON-2COOH@SiO 2 -MER (MER denotes mercaptosuccinic acid) microsphere for reversed-phase/hydrophilic interaction mixed-mode chromatography. SiO 2 was initially decorated with MON-2COOH using 2,5-dibromoterephthalic acid and tetrakis(4-ethynylphenyl)methane as monomers, and MER was then grafted via thiol-yne click reaction to yield MON-2COOH@SiO 2 -MER microspheres (5 μm) with a pore size of ~1.3 nm. The -COOH groups in 2,5-dibromoterephthalic acid and the post-modified MER molecules considerably improved the hydrophilicity of pristine MON and enhanced the hydrophilic interactions between the stationary phase and analytes. The retention mechanisms of the MON-2COOH@ SiO 2 -MER packed column were fully discussed

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Author

Hao-Fei Sun; Yuan-Yuan Cui; Hong-Liang Li; Cheng-Xiong Yang

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Chemistry (Physical Sciences)