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Can I read Effect of Bnu Treatment on Leukaemogenesis in Lethally Irradiated Akr Mice Restored with Bone-marrow and Spleen Cells on EtoBox?
Effect of Bnu Treatment on Leukaemogenesis in Lethally Irradiated Akr Mice Restored with Bone-marrow and Spleen Cells by H. Shisa; E. Legrand; R. Daculsi is a Medicine article available to read on EtoBox.
What is Effect of Bnu Treatment on Leukaemogenesis in Lethally Irradiated Akr Mice Restored with Bone-marrow and Spleen Cells about?
## Abstract The leukaemogenic effect of N‐butyl‐N‐nitrosourea (BNU) was studied in normal and thymectomized AKR mice which were lethally irradiated and restored with either bone‐marrow (BM) or spleen cells from (AKR × AKR/T1ALD)F~1~ donors. In some instances T1ALD thymic cells were added to the restorative inoculum. It was possible to determine the origin of the leukemic cells by the metacentric marker chromosomes of T1ALD. The T‐ or B‐cell characteristics were further ascertained by the cytotoxicity test for θ antigen and the EAC rosette test. All leukaemias whether thymic (TLS) or extra‐thymic (ETL), developed from donor bone‐marrow or spleen cells and never from the injected thymic cells. In non‐thymectomized animals BNU increased the percentage of TLS and shortened their latency. Most of TLS which occurred after BNU treatment of BM‐restored mice were θ‐negative whereas the majority of TLS which occurred in controls and in spleen‐restored animals were θ‐positive. This suggests that during their maturation process BM‐derived T precursors transit through a θ‐negative compartment. This compartment does not reach a similar size during the maturation process of the spleen‐derived pre
Who reads Effect of Bnu Treatment on Leukaemogenesis in Lethally Irradiated Akr Mice Restored with Bone-marrow and Spleen Cells?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- H. Shisa; E. Legrand; R. Daculsi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1977
- Language
- EN
- Field
- Medicine (Health Sciences)