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The Neuropsychological Profile of Early and Continuously Treated Phenylketonuria: Orienting, Vigilance, and Maintenance Versus Manipulation-functions of Working Memory by S.C.J Huijbregts; L.M.J de Sonneville; F.J van Spronsen; R Licht; J.A Sergeant is a Neuroscience article available to read on EtoBox.
What is The Neuropsychological Profile of Early and Continuously Treated Phenylketonuria: Orienting, Vigilance, and Maintenance Versus Manipulation-functions of Working Memory about?
In this paper, we review neuropsychological test results of early and continuously treated Phenylketonuria (PKU) patients. To increase insight into the neuropsychological profile of this population, we have attempted to place the results within an attentional network model [Images of the mind, 1994], which proposes interacting but dissociable attentional networks for orienting, vigilance, and executive control of attention. Executive control of attention is discussed against the background of the process-specific theory of working memory (WM) [Handbook of neuropsychology, 1994], which postulates a distinction between the 'maintenance'-function of WM and the 'manipulation and monitoring'-function. Neuropsychological results are presented for 67 early and continuously treated PKU patients and 73 controls aged 7-14 years. Four neuropsychological tasks were employed to measure orienting, mnemonic processing, interference suppression, and top-down control in visual search. No differences were found in orienting and the maintenance-function of WM. In addition to previously reported impairments in sustained attention/vigilance and inhibition of prepotent responding, PKU patients exhibited
Who reads The Neuropsychological Profile of Early and Continuously Treated Phenylketonuria: Orienting, Vigilance, and Maintenance Versus Manipulation-functions of Working Memory?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- S.C.J Huijbregts; L.M.J de Sonneville; F.J van Spronsen; R Licht; J.A Sergeant
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0149-7634)
- Published
- 2002
- Language
- EN
- Field
- Neuroscience (Life Sciences)