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Legacy effect of intensive glucose control on major adverse cardiovascular outcome: Systematic review and meta-analyses of trials according to different scenarios by Francesco Prattichizzo; Paola de Candia; Valeria De Nigris; Antonio Nicolucci; Antonio Ceriello is a Medicine article available to read on EtoBox.
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## Background: Early and intensive glycaemic control provides long-term protection against the development of microvascular complications, a phenomenon defined legacy effect. whether a legacy effect of high glucose exists also on macrovascular endpoints is uncertain. ## Methods and findings: We performed a systematic review of both randomized clinical trials (rct)s and observational studies pertinent to the research question. we searched pubmed, embase, scopus and the cochrane database up to january 31th 2020. eligibility criteria for rcts were: 1 - efficacy assessment of intensive glucose lowering treatment vs a less-stringent/conventional treatment; 2 - the inclusion of a post-active phase, observational follow-up; 3 - enrolment of patients with t1dm, pre-diabetes, and t2dm; and 4 - data report on major adverse cardiovascular events (mace) incidence, which was the primary endpoint of this meta-analysis. we performed multiple meta-analyses of the available rcts according to different scenarios considering the type of diabetes, diabetes duration, the presence of previous cardiovascular events, follow-up extension, and the incidence of mace recorded only during the observational, po
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- Author
- Francesco Prattichizzo; Paola de Candia; Valeria De Nigris; Antonio Nicolucci; Antonio Ceriello
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)