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Effect of Erythrocytapheresis on Arterial Oxygen Saturation and Hemoglobin Oxygen Affinity in Patients with Sickle Cell Disease by Uchida, Kou; Rackoff, Wayne R.; Ohene-Frempong, Kwaku; Kim, Haewon C.; Reilly, Michael P.; Asakura, Toshio is a Medicine article available to read on EtoBox.
What is Effect of Erythrocytapheresis on Arterial Oxygen Saturation and Hemoglobin Oxygen Affinity in Patients with Sickle Cell Disease about?
An important purpose of blood transfusion in patients with sickle cell disease is to improve arterial oxygen saturation (SaO 2 ) and thereby reduce red cell sickling. To investigate the degree of improvement in SaO 2 by blood transfusion, we determined the hemoglobin oxygen affinity, transcutaneous oxygen saturation (Tc-SO 2 ), and pulse rate before and after automated partial exchange transfusion (erythrocytapheresis). In 13 patients with sickle cell disease who underwent 24 erythrocytapheresis procedures, the mean oxygen tension at half saturation (P50) was significantly reduced from 30.4 ± 2.2 to 26.0 ± 1.6 mm Hg (P < 0.01) immediately after exchange transfusion. Mean Tc-SO 2 values increased from 96.2 ± 2.8 to 98.5 ± 2.1% (P < 0.01). Approximately 50% of the increase in Tc-SO 2 after erythrocytapheresis could be explained by the increase in hemoglobin oxygen affinity. An increase in arterial oxygen pressure (PaO 2 ) following erythrocytapheresis, suggested by the calculated PaO 2 in this study, may explain some of the increase in Tc-SO 2 . We conclude that improvement in Tc-SO 2 in patients with sickle cell disease resulted from changes in hemoglobin oxygen affinity as well as
Who reads Effect of Erythrocytapheresis on Arterial Oxygen Saturation and Hemoglobin Oxygen Affinity in Patients with Sickle Cell Disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Uchida, Kou; Rackoff, Wayne R.; Ohene-Frempong, Kwaku; Kim, Haewon C.; Reilly, Michael P.; Asakura, Toshio
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0361-8609)
- Published
- 1998
- Language
- EN
- Field
- Medicine (Health Sciences)