Can I read MRI lesions as a surrogate for relapses in multiple sclerosis: a meta-analysis of randomised trials on EtoBox?

MRI lesions as a surrogate for relapses in multiple sclerosis: a meta-analysis of randomised trials by Maria Pia Sormani; Paolo Bruzzi is a Medicine article available to read on EtoBox.

What is MRI lesions as a surrogate for relapses in multiple sclerosis: a meta-analysis of randomised trials about?

## Background: A meta-analysis of randomised trials in relapsing-remitting multiple sclerosis published in 2009 showed a quantitative relation between the treatment effects detected on mri lesions and clinical relapses. we aimed to validate that relation using data from a large and independent set of clinical trials in multiple sclerosis. ## Methods: We searched medline for clinical trials that assessed disease-modifying drugs for relapsing-remitting multiple sclerosis published from sept 1, 2008, to oct 31, 2012. we extracted data for the treatment effects on mri lesions and on relapses from each trial, and the correlation of log transformed relative measures of these treatment effects was assessed with a weighted linear regression analysis. the r(2) value was estimated to quantify the strength of the correlation, and we used an interaction test to test for a difference in slope from the previously estimated equation. we also ran several sensitivity analyses. ## Findings: We identified 31 eligible trials, which provided data for 18 901 patients with relapsing-remitting multiple sclerosis. the regression equation derived using data from these studies showed a relation between the c

Who reads MRI lesions as a surrogate for relapses in multiple sclerosis: a meta-analysis of randomised trials?

Author

Maria Pia Sormani; Paolo Bruzzi

Publisher

Elsevier BV

Published

2013

Language

EN

Field

Medicine (Health Sciences)