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Can I read The Development and Benefits of Metformin in Various Diseases on EtoBox?
The Development and Benefits of Metformin in Various Diseases by Ying Dong; Yingbei Qi; Haowen Jiang; Tian Mi; Yunkai Zhang; Chang Peng; Wanchen Li; Yongmei Zhang; Yubo Zhou; Yi Zang; Jia Li is a Medicine article available to read on EtoBox.
What is The Development and Benefits of Metformin in Various Diseases about?
Metformin has been used for the treatment of type II diabetes mellitus for decades due to its safety, low cost, and outstanding hypoglycemic effect clinically. The mechanisms underlying these benefits are complex and still not fully understood. Inhibition of mitochondrial respiratory-chain complex I is the most described downstream mechanism of metformin, leading to reduced ATP production and activation of AMP-activated protein kinase (AMPK). Meanwhile, many novel targets of metformin have been gradually discovered. In recent years, multiple pre-clinical and clinical studies are committed to extend the indications of metformin in addition to diabetes. Herein, we summarized the benefits of metformin in four types of diseases, including metabolic associated diseases, cancer, aging and age-related diseases, neurological disorders. We comprehensively discussed the pharmacokinetic properties and the mechanisms of action, treatment strategies, the clinical application, the potential risk of metformin in various diseases. This review provides a brief summary of the benefits and concerns of metformin, aiming to interest scientists to consider and explore the common and specific mechanisms
Who reads The Development and Benefits of Metformin in Various Diseases?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ying Dong; Yingbei Qi; Haowen Jiang; Tian Mi; Yunkai Zhang; Chang Peng; Wanchen Li; Yongmei Zhang; Yubo Zhou; Yi Zang; Jia Li
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)