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Mid-life Peripheral Arterial Stiffness Predicts Cognitive Impairment In Older Adults: Insight From Heartscore Study by Anum Saeed; Patrick Strollo; Steven E. Reis; Oladipupo Olafiranye is a Medicine article available to read on EtoBox.

What is Mid-life Peripheral Arterial Stiffness Predicts Cognitive Impairment In Older Adults: Insight From Heartscore Study about?

Background: Cognitive impairment is a major cause of disability and mortality among older adults. Studies have reported an association between cardiovascular disease (CVD) risk factors and cognitive impairment in the elderly. However, little is known about the predictive value of subclinical atherosclerosis at mid-life on cognitive impairment at late-life. We assessed the impact of peripheral arterial stiffness during mid-life on cognitive function a decade later. ## Methods: We used data from Heart Strategies Concentrating on Risk Evaluation (HeartSCORE) study. The HeartSCORE study is a community-based prospective study assessing cardiovascular risks in a racially diverse population in Pittsburgh, U.S. Arterial stiffness and wave reflection were measured at study entry using the Endo-PAT device and expressed as heart rate-adjusted augmentation index (AI75). Higher AI75 denotes higher arterial stiffness and wave reflection. For statistical analysis, AI75 was categorized into terciles. Objective cognition was assessed 10-12 years after study entry using the Montreal Cognitive Assessment (MoCA). A MoCA score of <27 was considered impaired cognitive function. A total of 836 Heart SCOR

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Author

Anum Saeed; Patrick Strollo; Steven E. Reis; Oladipupo Olafiranye

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)