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Can I read Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis on EtoBox?
Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis by Hélène Catoire; Patrick A. Dion; Lan Xiong; Mourabit Amari; Rebecca Gaudet; Simon L. Girard; Anne Noreau; Claudia Gaspar; Gustavo Turecki; Jacques Y. Montplaisir; J. Alex Parker; Guy A. Rouleau is a Medicine article available to read on EtoBox.
What is Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis about?
## Abstract Restless legs syndrome (RLS) is a frequent sleep disorder that is linked to disturbed iron homeostasis. Genetic studies identified __MEIS1__ as an RLS‐predisposing gene, where the RLS risk haplotype is associated with decreased MEIS1 mRNA and protein expression. We show here that RNA interference treatment of the __MEIS1__ worm orthologue increases ferritin expression in __Caenorhabditis elegans__ and that the RLS‐associated haplotype leads to increased expression of ferritin and __DMT1__ in RLS brain tissues. Additionally, human cells cultured under iron‐deficient conditions show reduced MEIS1 expression. Our data establish a link between the RLS __MEIS1__ gene and iron metabolism. Ann Neurol 2011;
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- Author
- Hélène Catoire; Patrick A. Dion; Lan Xiong; Mourabit Amari; Rebecca Gaudet; Simon L. Girard; Anne Noreau; Claudia Gaspar; Gustavo Turecki; Jacques Y. Montplaisir; J. Alex Parker; Guy A. Rouleau
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0364-5134)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)