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Can I read New amidine-benzenesulfonamides as iNOS inhibitors for the therapy of the triple negative breast cancer on EtoBox?
New amidine-benzenesulfonamides as iNOS inhibitors for the therapy of the triple negative breast cancer by M. Dora Carrión; Belén Rubio-Ruiz; Francisco Franco-Montalban; Pasquale Amoia; Maria Chiara Zuccarini; Chiara De Simone; M. Encarnación Camacho; Rosa Amoroso; Cristina Maccallini is a Chemistry article available to read on EtoBox.
What is New amidine-benzenesulfonamides as iNOS inhibitors for the therapy of the triple negative breast cancer about?
Triple negative breast cancer (TNBC) is a specific breast cancer subtype, and poor prognosis is associated to this tumour when it is in the metastatic form. The overexpression of the inducible Nitric Oxide Synthase (iNOS) is considered a predictor of poor outcome in TNBC patients, and this enzyme is reported as a valuable molecular target to compromise TNBC progression. In this work, new amidines containing a benzenesulfonamide group were designed and synthesized as selective iNOS inhibitors. An in vitro biological evaluation was performed to assess compounds activity against both the inducible and constitutive NOSs. The most interesting compounds 1b and 2b were evaluated on MDA-MB-231 cells as antiproliferative agents, and 1b capability to counteract cell migration was also studied. Finally, an in-depth docking study was performed to shed light on the observed potency and selectivity of action of the most promising compounds.
Who reads New amidine-benzenesulfonamides as iNOS inhibitors for the therapy of the triple negative breast cancer?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- M. Dora Carrión; Belén Rubio-Ruiz; Francisco Franco-Montalban; Pasquale Amoia; Maria Chiara Zuccarini; Chiara De Simone; M. Encarnación Camacho; Rosa Amoroso; Cristina Maccallini
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Chemistry (Physical Sciences)