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Innate lymphoid cells exhibited IL-17-expressing phenotype in active tuberculosis disease by Pan, Linyue (author);Chen, Xiaoli (author);Liu, Xuanqi (author);Qiu, Wenjia (author);Liu, Yunhuan (author);Jiang, Weiping (author);Zheng, Yang (author);Mou, Yan (author);Xu, Wei (author);Li, Xiangyang (author);Ge, Haiyan (author);Zhu, Huili (author) is a Medicine article available to read on EtoBox.

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## Background: Innate lymphoid cells (ilcs), as an important group of innate immunity, could respond rapidly to mycobacterium tuberculosis (mtb) infection. in this research, we studied the phenotypic changes of circulatory ilcs in active tuberculosis (tb) disease. ## Methods: We recruited 40 patients with active mtb infection (tb group) and 41 healthy subjects (nc group), and collected their clinical information and peripheral blood. circulating ilcs, ilc subsets, dendritic cells (dcs), macrophages, and the production of cytokines in ilcs were tested by flow cytometry (fcm). enzyme-linked immunosorbent assay (elisa) was used to detect plasma il-23. ## Results: Compared with healthy control, total ilcs (0.73% vs. 0.42%, p = 0.0019), ilc1 (0.55% vs. 0.31%, p = 0.0024) and cd117 ilc2 (0.02% vs. 0.01%, p = 0.0267) were upregulated in tb group. the total il-17 lymphocytes were elevated (3.83% vs. 1.76%, p = 0.0006) while the il-22 lymphocytes remained unchanged. within ilc subsets, ilc3, cd117 ilc2 and ilc1 in tb group all expressed increased il-17 (15.15% vs. 4.55%, 19.01% vs. 4.57%, 8.79% vs. 3.87%, p < 0.0001) but similar il-22 comparing with healthy control. tb group had more plasma

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Author

Pan, Linyue (author);Chen, Xiaoli (author);Liu, Xuanqi (author);Qiu, Wenjia (author);Liu, Yunhuan (author);Jiang, Weiping (author);Zheng, Yang (author);Mou, Yan (author);Xu, Wei (author);Li, Xiangyang (author);Ge, Haiyan (author);Zhu, Huili (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)