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Highly Expressed DLL4 and JAG1: Their Role in Incidence of Breast Cancer Metastasis by Samir F. Zohny; Mazin A. Zamzami; Abdulrahman L. Al-Malki; Nora H. Trabulsi is a Medicine article available to read on EtoBox.

What is Highly Expressed DLL4 and JAG1: Their Role in Incidence of Breast Cancer Metastasis about?

## Background: The role of notch signaling dysregulation in causing metastatic breast cancer is not yet elucidated, therefore, this study aimed to investigate the expression of dll4 and jag1 in metastatic breast cancer. moreover, we examined the possible association between clinicopathological features and studied parameters. ## Design and methods: A total of 90 patients with invasive ductal breast carcinomas (52 non-metastatic and 38 metastatic) were enrolled in the current study. furthermore, there were 42 patients with benign breast diseases. the mrna and protein expression of dll4 and jag1 were analyzed by rt-pcr and elisa, respectively in breast cell lysates. ## Results: The mrna and protein expression of dll4 and jag1 were obviously higher in patients with breast cancer compared to patients with benign breast diseases and in metastatic versus non-metastatic breast cancer. a significant positive correlation was declared between dll4 and jag1 at both mrna and protein levels in metastatic and localized breast cancer patients. highly expressed mrna and protein of dll4 and jag1 were associated with late tumor stages; moreover, upregulation of mrna and protein of jag1 was correlate

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Author

Samir F. Zohny; Mazin A. Zamzami; Abdulrahman L. Al-Malki; Nora H. Trabulsi

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0188-4409)

Published

2020

Language

EN

Field

Medicine (Health Sciences)