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Feasibility study of inhaled hepatitis B vaccine formulated with tetradecylmaltoside by Chandan Thomas; Amit Rawat; Shuhua Bai; Fakhrul Ahsan is a Chemistry article available to read on EtoBox.
What is Feasibility study of inhaled hepatitis B vaccine formulated with tetradecylmaltoside about?
This study was designed to test the hypothesis that formulation of hepatitis B vaccine with tetradecyl-b-maltoside (TDM) enhances the immune response after pulmonary administration in a rodent model. Commercially available recombinant hepatitis B vaccine (rHBV) was formulated with varying concentrations of TDM and administered intratracheally to anesthetized male Sprague-Dawley rats. rHBV administered intramuscularly at doses of 2 and 4 mg served as positive controls. All formulations were administered on days 0 and 14 and the immune response was evaluated for 28 days. Specific antibodies generated to HBsAg were analyzed by ELISA. Safety studies were carried out by measuring the levels of alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and tumor necrosis factor a (TNF-a) in bronchoalveolar lavage (BAL) fluid. There was a significant increase in the immune response when the vaccine was administered intramuscularly at a dose of 4 mg. Only a modest increase in the immune response was observed when plain rHBV was administered intratracheally at the same dose. However, a pulmonary formulation of 4 mg rHBV plus 0.5% TDM produced a fourfold increase in the immune response compared
Who reads Feasibility study of inhaled hepatitis B vaccine formulated with tetradecylmaltoside?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Chandan Thomas; Amit Rawat; Shuhua Bai; Fakhrul Ahsan
- Publisher
- John Wiley and Sons; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-3549)
- Published
- 2008
- Language
- EN
- Field
- Chemistry (Physical Sciences)