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ADARs catalyze adenosine to inosine editing within dsRNA substrates. These changes create codons for a different amino acid, stop codons or even a new splice-site allowing protein diversity generated from a single gene. Any imbalance of the gene expression can impair neurological functions and lead to severe diseases such as brain cancer, schizophrenia or neuromuscular and neurodegenerative syndromes.
- Author
- Irina Odajiu
- Language
- EN