Can I read Effect of pycnogenol^®^ on glucose transport in mature 3T3‐L1 Adipocytes on EtoBox?

Effect of pycnogenol^®^ on glucose transport in mature 3T3‐L1 Adipocytes by Hee-Hyun Lee; Kui-Jin Kim; Ok-Hwan Lee; Boo-Yong Lee is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Effect of pycnogenol^®^ on glucose transport in mature 3T3‐L1 Adipocytes about?

## Abstract Pycnogenol^®^, a procyanidins‐enriched extract of __Pinus maritima__ bark, possesses antidiabetic properties, which improves the altered parameters of glucose metabolism that are associated with type 2 diabetes mellitus (T2DM). Since the insulin‐stimulated antidiabetic activities of natural bioactive compounds are mediated by GLUT4 via the phosphatidylinositol‐3‐kinase (PI3K) and/or p38 mitogen activated protein kinase (p38‐MAPK) pathway, the effects of pycnogenol^®^ were examined on the molecular mechanism of glucose uptake by the glucose transport system. 3T3‐L1 adipocytes were treated with various concentrations of pycnogenol^®^, and glucose uptake was examined using a non‐radioisotope enzymatic assay and by molecular events associated with the glucose transport system using semi‐quantitative reverse transcription‐polymerase chain reaction (RT‐PCR). The results show that pycnogenol^®^ increased glucose uptake in fully differentiated 3T3‐L1 adipocytes and increased the relative abundance of both GLUT4 and Akt mRNAs through the PI3K pathway in a dose dependent manner. Furthermore, pycnogenol^®^ restored the PI3K antagonist‐induced inhibition of glucose uptake in the pr

Who reads Effect of pycnogenol^®^ on glucose transport in mature 3T3‐L1 Adipocytes?

Author

Hee-Hyun Lee; Kui-Jin Kim; Ok-Hwan Lee; Boo-Yong Lee

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)