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Can I read The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity on EtoBox?
The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity by Jiajia Zhou; Ilona Kryczek; Shasha Li; Xiong Li; Angelo Aguilar; Shuang Wei; Sara Grove; Linda Vatan; Jiali Yu; Yijian Yan; Peng Liao; Heng Lin; Jing Li; Gaopeng Li; Wan Du; Weichao Wang; Xueting Lang; Weimin Wang; Shaomeng Wang; Weiping Zou is a Immunology and Microbiology article available to read on EtoBox.
What is The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity about?
oss of tumor-suppressive function of p53 through TP53 gene deletion or mutation is the most frequent event in human cancers. Approximately 50% of human cancers retain a wild-type TP53 allele, but the tumor-suppressive function of p53 is attenuated by mouse double minute 2 (MDM2) and other signaling modules. Because MDM2 inhibits p53 activity through its direct interaction, one cancer therapeutic approach is the development of small-molecule inhibitors of the p53-MDM2 interaction to reactivate p53 in tumor cells [1][2][3][4] . Indeed, a number of small-molecule inhibitors of the p53-MDM2 interaction are in clinical development. MDM2 also has oncogenic activity independent of p53. Other therapeutic approaches targeting MDM2 have also been pursued 1,5, . Despite these efforts, no therapy targeting MDM2 has been approved. Therefore, we reason that the frustration of cancer therapeutic application exists due to a gap in the substantial knowledge of the p53-MDM2 pathway in the fields of tumor biology and oncology, and the limited understanding of this pathway in T cells in the context of tumor immunology.Immunotherapy is an effective remedy to treat patients with cancer 7-9 . CD8 + T cel
Who reads The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Jiajia Zhou; Ilona Kryczek; Shasha Li; Xiong Li; Angelo Aguilar; Shuang Wei; Sara Grove; Linda Vatan; Jiali Yu; Yijian Yan; Peng Liao; Heng Lin; Jing Li; Gaopeng Li; Wan Du; Weichao Wang; Xueting Lang; Weimin Wang; Shaomeng Wang; Weiping Zou
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)